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Genome-wide analysis of gene expression profile of Intestinal (COLON) Tumors from APCmin/+/VP16LXRa vs APCmin/+/VP16

ABSTRACT: Changes in gene expression profile of intestinal (COLON) Tumors from APCmin/+/VP16LXRa vs APCmin/+/VP16. The hypothesis tested in the present study was that LXRa overexpression influence cancer growth modulating lipid metabolism in cancer cells. Results provide the information that LXRa induces expression of genes encoding proteins able to regulate cholesterol efflux. Total RNA obtained from colonic tumors from APCmin/+/VP16LXRa mice was compared to total RNA extracted from APCmin/+/VP16 mice.

ORGANISM(S): Mus musculus

SUBMITTER: Antonio Moschetta 

PROVIDER: E-GEOD-44070 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.

Lo Sasso Giuseppe G   Bovenga Fabiola F   Murzilli Stefania S   Salvatore Lorena L   Di Tullio Giuseppe G   Martelli Nicola N   D'Orazio Andria A   Rainaldi Stefania S   Vacca Michele M   Mangia Anita A   Palasciano Giuseppe G   Moschetta Antonio A  

Gastroenterology 20130216 7

<h4>Background & aims</h4>Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated whether expression of activated LXR protects against intestinal tumorigenesis in mice.<h4>Methods</h4>We analyzed the development of colon cancer in mice that express a con  ...[more]

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