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Genome-wide analysis of gene expression profile of Xenograft Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with Control (Ad-VP16) or LXRa (VP16hLXRa) Adenovirus

ABSTRACT: Changes in gene expression profile of Xenograft Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with Control (Ad-VP16) or LXRa (VP16hLXRa) Adenovirus. The hypothesis tested in the present study was that LXRa overexpression influence cancer growth modulating lipid metabolism in cancer cells. Results provide the information that LXRa induces genes encoding proteins able to regulate cholesterol efflux thus reducing tumor growth. Total RNA obtained from Xenograft Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with LXRa (VP16hLXRa) Adenovirus was compared to total RNA extracted from Xenografted Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with Control (Ad-VP16) Adenovirus.

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Moschetta 

PROVIDER: E-GEOD-44068 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.

Lo Sasso Giuseppe G   Bovenga Fabiola F   Murzilli Stefania S   Salvatore Lorena L   Di Tullio Giuseppe G   Martelli Nicola N   D'Orazio Andria A   Rainaldi Stefania S   Vacca Michele M   Mangia Anita A   Palasciano Giuseppe G   Moschetta Antonio A  

Gastroenterology 20130216 7

<h4>Background & aims</h4>Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated whether expression of activated LXR protects against intestinal tumorigenesis in mice.<h4>Methods</h4>We analyzed the development of colon cancer in mice that express a con  ...[more]

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