Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Antonio Moschetta
PROVIDER: E-GEOD-44071 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gastroenterology 20130216 7
<h4>Background & aims</h4>Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated whether expression of activated LXR protects against intestinal tumorigenesis in mice.<h4>Methods</h4>We analyzed the development of colon cancer in mice that express a con ...[more]