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Antenatal Blood DNA Methylation Profiles

ABSTRACT: DNA methylation profiles were generating using Illumina HM450 microarrays in a prospective sample blood from the prenatal period of pregnant mood disorder patients who would and would not develop depression post partum. We recruited 54 pregnant women with a history of either Major Depression or Bipolar Disorder (I, II or NOS) and prospectively followed them during pregnancy and after delivery in order to identify genetic and clinical characteristics that precede the development of a postpartum depressive episode. Blood samples profiled were collected at varying time points during pregnancy.

ORGANISM(S): Homo sapiens

SUBMITTER: Jerry Guintivano

PROVIDER: E-GEOD-44132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Antenatal prediction of postpartum depression with blood DNA methylation biomarkers.

Guintivano J J Arad M M Gould T D TD Payne J L JL Kaminsky Z A ZA

Molecular psychiatry 20130521 5

Postpartum depression (PPD) affects ∼10-18% of women in the general population and results in serious consequences to both the mother and offspring. We hypothesized that predisposition to PPD risk is due to an altered sensitivity to estrogen-mediated epigenetic changes that act in a cell autonomous manner detectable in the blood. We investigated estrogen-mediated epigenetic reprogramming events in the hippocampus and risk to PPD using a cross-species translational design. DNA methylation profile ...[more]

PMID: 23689534

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