Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from human foreskin fibroblasts (HFFs) infected with type I strains of Toxoplasma gondii.


ABSTRACT: Type I strains of Toxoplasma gondii exhibit phenotypic variation, but it is uncertain how differently type I strains modulate the host cell. We determined differential host modulation by type I strains through microarray. HFFs were infected with RH-ERP, RH-JSR and GT1 for 24 hours. Total RNA was isolated and hybridized to Affymetrix GeneChip Human Genome U133A 2.0 arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Ninghan Yang 

PROVIDER: E-GEOD-44189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains.

Yang Ninghan N   Farrell Andrew A   Niedelman Wendy W   Melo Mariane M   Lu Diana D   Julien Lindsay L   Marth Gabor T GT   Gubbels Marc-Jan MJ   Saeij Jeroen P J JP  

BMC genomics 20130710


<h4>Background</h4>Toxoplasma gondii has a largely clonal population in North America and Europe, with types I, II and III clonal lineages accounting for the majority of strains isolated from patients. RH, a particular type I strain, is most frequently used to characterize Toxoplasma biology. However, compared to other type I strains, RH has unique characteristics such as faster growth, increased extracellular survival rate and inability to form orally infectious cysts. Thus, to identify candida  ...[more]

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