Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of E. coli SL2 cells treated with cycloheximide and LPS


ABSTRACT: E. coli lipopolysacharide was treated on SL2* cells for 1hr, 4 and 12hrs respectivly. cDNA from those cells was compared with control. For one sample, cyclohexamide was treated for 1hr and then LPS was treated for 4hrs. Then, compared with control.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Joon Kim 

PROVIDER: E-MEXP-172 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules.

Kim Taeil T   Yoon Joonsun J   Cho Hwansung H   Lee Wook-Bin WB   Kim Joon J   Song Young-Hwa YH   Kim Se Nyun SN   Yoon Jeong Ho JH   Kim-Ha Jeongsil J   Kim Young-Joon YJ  

Nature immunology 20050109 2


IkappaB kinase (IKK) and Jun N-terminal kinase (Jnk) signaling modules are important in the synthesis of immune effector molecules during innate immune responses against lipopolysaccharide and peptidoglycan. However, the regulatory mechanisms required for specificity and termination of these immune responses are unclear. We show here that crosstalk occurred between the drosophila Jnk and IKK pathways, which led to downregulation of each other's activity. The inhibitory action of Jnk was mediated  ...[more]

Similar Datasets

2004-10-01 | E-MEXP-177 | biostudies-arrayexpress
2012-11-01 | E-GEOD-41794 | biostudies-arrayexpress
2009-10-29 | E-GEOD-17991 | biostudies-arrayexpress
2010-06-25 | E-GEOD-16872 | biostudies-arrayexpress
2012-11-01 | E-GEOD-40099 | biostudies-arrayexpress
2012-09-28 | E-GEOD-41120 | biostudies-arrayexpress
2007-01-09 | E-MEXP-527 | biostudies-arrayexpress
2009-01-06 | E-MEXP-1965 | biostudies-arrayexpress
2009-06-11 | E-MEXP-1964 | biostudies-arrayexpress
2008-12-19 | E-MEXP-1959 | biostudies-arrayexpress