TLR7 gene duplication accelerates autoimmunity and promotes nucleolar-specific B cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Prapaporn Pisitkun
PROVIDER: E-GEOD-4445 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.
Pisitkun Prapaporn P Deane Jonathan A JA Difilippantonio Michael J MJ Tarasenko Tatyana T Satterthwaite Anne B AB Bolland Silvia S
Science (New York, N.Y.) 20060518 5780
Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor. The TLR7 gene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region. T ...[more]
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