Drosophila elevated CO2 (hypercapnia) microarray
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Taneli Helenius
PROVIDER: E-GEOD-17444 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection.
Helenius Iiro Taneli IT Krupinski Thomas T Turnbull Douglas W DW Gruenbaum Yosef Y Silverman Neal N Johnson Eric A EA Sporn Peter H S PH Sznajder Jacob I JI Beitel Greg J GJ
Proceedings of the National Academy of Sciences of the United States of America 20091021 44
Elevated CO(2) levels (hypercapnia) frequently occur in patients with obstructive pulmonary diseases and are associated with increased mortality. However, the effects of hypercapnia on non-neuronal tissues and the mechanisms that mediate these effects are largely unknown. Here, we develop Drosophila as a genetically tractable model for defining non-neuronal CO(2) responses and response pathways. We show that hypercapnia significantly impairs embryonic morphogenesis, egg laying, and egg hatching ...[more]
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