Dataset Information
Mouse Spontaneous C3H/HeJ AA Skin
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ali Jabbari
PROVIDER: E-GEOD-45513 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
Nature medicine 20140817 9
Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8(+)NKG2D(+) T cells are both necessary and sufficient for the induction of AA i ...[more]
