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Small RNA expression signatures of gastrointestinal stromal tumors: associations to imatinib resistance and patient outcome

ABSTRACT: We performed miRNA expression profiling in a series of fresh-frozen neoadjuvantly imatinib treated gastrointestinal stromal tumors (GIST), using a microarray approach. Significant differentially expressed miRNAs among imatinib-resistant and imatinib-sensitive groups were identified using SAM analysis. Agilent microarray platform with probes matching 903 human miRNAs was used to determine miRNA expression profiles in 17 GISTs (imatinib-sensitive and 7 imatinib-resistant). To validate the microarray platform, the expression levels of selected miRNAs were evaluated using qRT-PCR.

ORGANISM(S): Homo sapiens

SUBMITTER: Pinar Akcakaya

PROVIDER: E-GEOD-45901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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