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Analyses of mIRNA transcript level following exposure to triptolide

ABSTRACT: Analyses of mirna transcript levels following exposure to the drug triptolide in vitro and prodrug minnelide in xenograft pancreatic tumor mouse models. Response of pancreatic adenocarcinoma cell lines to minelide in vitro and exposure to its prodrug triptolide in SCID mouse tumors derived from the same cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Aaron Sarver

PROVIDER: E-GEOD-46188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.

MacKenzie Tiffany N TN Mujumdar Nameeta N Banerjee Sulagna S Sangwan Veena V Sarver Aaron A Vickers Selwyn S Subramanian Subbaya S Saluja Ashok K AK

Molecular cancer therapeutics 20130501 7

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest malignancies, is resistant to current chemotherapies. We previously showed that triptolide inhibits PDAC cell growth in vitro and blocks metastatic spread in vivo. Triptolide downregulates HSP70, a molecular chaperone upregulated in several tumor types. This study investigates the mechanism by which triptolide inhibits HSP70. Because microRNAs (miRNA) are becoming increasingly recognized as negative regulators of gene expression, we t ...[more]

PMID: 23635652

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Evaluation of a New High-Dimensional miRNA Profiling Platform

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Analyses of mIRNA transcript level following exposure to triptolide

Project description:Analyses of mirna transcript levels following exposure to the drug triptolide in vitro and prodrug minnelide in xenograft pancreatic tumor mouse models.

2013-11-12 | GSE46188 | GEO

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Dysregulation of lncRNAs and circRNAs in mouse testes after exposure to triptolide

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2020-03-23 | GSE126857 | GEO

The genes affected by Triptolide in activated mouse primary T cells

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