Unknown,Transcriptomics,Genomics,Proteomics

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State- and trait-specific gene expression in euthymia and mania


ABSTRACT: Gene expression profiles of bipolar disorder (BD) patients were assessed during both a manic and a euthymic phase and compared both intra-individually, and with the gene expression profiles of controls. 11 BD patients were assessed in their manic as well as in their euthymic phase. Comparison of gene expression BD euthymic vs. controls, BD manic vs. controls, and intra-patient comparison BD euthymic vs. BD manic.

ORGANISM(S): Homo sapiens

SUBMITTER: Carsten Sticht 

PROVIDER: E-GEOD-46416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder.

Witt S H SH   Juraeva D D   Sticht C C   Strohmaier J J   Meier S S   Treutlein J J   Dukal H H   Frank J J   Lang M M   Deuschle M M   Schulze T G TG   Degenhardt F F   Mattheisen M M   Brors B B   Cichon S S   Nöthen M M MM   Witt C C CC   Rietschel M M  

Translational psychiatry 20140819


Bipolar disorder (BD) is a highly heritable psychiatric disease characterized by recurrent episodes of mania and depression. To identify new BD genes and pathways, the present study employed a three-step approach. First, gene-expression profiles of BD patients were assessed during both a manic and an euthymic phase. These profiles were compared intra-individually and with the gene-expression profiles of controls. Second, those differentially expressed genes that were considered potential trait m  ...[more]

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