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The Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Peter Park

PROVIDER: E-GEOD-46588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters.

Tolstorukov Michael Y MY Sansam Courtney G CG Lu Ping P Koellhoffer Edward C EC Helming Katherine C KC Alver Burak H BH Tillman Erik J EJ Evans Julia A JA Wilson Boris G BG Park Peter J PJ Roberts Charles W M CW

Proceedings of the National Academy of Sciences of the United States of America 20130530 25

Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established, are dynamically maintained, and subsequently contribute to transcriptional control are poorly understood. The switch/sucrose non-fermentable chromatin remodeling complex, also known as the Brg1 associated factors complex, is a master developmental regulator and tumor suppressor capable of mobilizing nucleosomes in ...[more]

PMID: 23723349

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The Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [ChIP-seq]

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