Unknown,Transcriptomics,Genomics,Proteomics

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Global gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Heather Wick 

PROVIDER: E-GEOD-47394 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome.

Hui Lisa L   Wick Heather C HC   Moise Kenneth J KJ   Johnson Anthony A   Luks Francois F   Haeri Sina S   Johnson Kirby L KL   Bianchi Diana W DW  

Prenatal diagnosis 20130604 9


<h4>Objective</h4>The objective of this study was to understand the biological pathways involved in twin-twin transfusion syndrome (TTTS) by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA.<h4>Methods</h4>A prospective whole transcriptome microarray study analyzing cell-free RNA in AF from TTTS recipient twins and singleton controls was carried out. Significantly differentially regulated genes in TTTS cases (N = 8) versus matched controls (N = 8) were identified a  ...[more]

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