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Gata6

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Enrique Carrillo de Santa Pau

PROVIDER: E-GEOD-47537 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.

Martinelli Paola P Madriles Francesc F Cañamero Marta M Pau Enrique Carrillo-de Santa EC Pozo Natalia Del ND Guerra Carmen C Real Francisco X FX

Gut 20150116 3

<h4>Background and aims</h4>Gata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent acinar-ductal metaplasia, which is considered an initial step of mutant KRas-driven carcinogenesis. Therefore, the Gata6-null pancreas might represent a tumour-prone environment. We investigated whether Gata6 plays a role during pancreatic tumorigenesis.<h4>Design</h4>We analysed genetically engine ...[more]

PMID: 25596178

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