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Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: jasmine jacob

PROVIDER: E-GEOD-47998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR).

Solomon Oz O Oren Shirley S Safran Michal M Deshet-Unger Naamit N Akiva Pinchas P Jacob-Hirsch Jasmine J Cesarkas Karen K Kabesa Reut R Amariglio Ninette N Unger Ron R Rechavi Gideon G Eyal Eran E

RNA (New York, N.Y.) 20130308 5

Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been linked to splicing regulation in several cases. Here we used bioinformatics approaches, RNA-seq and exon-specific microarray of ADAR knockdown cells to globally examine how ADAR and its A-to-I RNA ed ...[more]

PMID: 23474544

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