BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: James Bradner
PROVIDER: E-GEOD-48112 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
BET bromodomains mediate transcriptional pause release in heart failure.
Anand Priti P Brown Jonathan D JD Lin Charles Y CY Qi Jun J Zhang Rongli R Artero Pedro Calderon PC Alaiti M Amer MA Bullard Jace J Alazem Kareem K Margulies Kenneth B KB Cappola Thomas P TP Lemieux Madeleine M Plutzky Jorge J Bradner James E JE Haldar Saptarsi M SM
Cell 20130801 3
Heart failure (HF) is driven by the interplay between regulatory transcription factors and dynamic alterations in chromatin structure. Pathologic gene transactivation in HF is associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylation. We therefore assessed the role of acetyl-lysine reader proteins, or bromodomains, in HF. Using a chemical genetic approach, we establish a central role for BET family bromodomain proteins in gene control during HF pathogenesis. ...[more]
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