Unknown,Transcriptomics,Genomics,Proteomics

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Designed Oligooxopiperazines as Modulators of Hypoxia-Inducible Factor Signaling


ABSTRACT: We performed gene expression profiling for designed oligooxopiperazines targeting the hypoxia-inducible transcription factor complex, which resulted in an effective inhibition of hypoxia-inducible genes with relatively minimal perturbation of non-targeted signaling pathways. Hypoxic A549 cells were treated with transcriptional inhibitors BB2-162, BB2-125, BB2-282 or vehicle and their expression profiles were compared to normoxic A549 cells treated with vehicle.

ORGANISM(S): Homo sapiens

SUBMITTER: Bogdan Olenyuk 

PROVIDER: E-GEOD-48134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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