Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Shaun Mahony
PROVIDER: E-GEOD-48254 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stem cell reports 20131107 5
Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight into Cdx4 function, we performed chromatin immunoprecipitation sequencing (ChIP-seq) combined with gene-expression profiling in zebrafish, and identified the transcription factor spalt-like 4 (sall4) as a Cdx4 target. ChIP-seq revealed that Sall4 bound to its own gene locus and th ...[more]