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Unknown,Transcriptomics,Genomics,Proteomics

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The Wnt/β-catenin-signaling pathway is modulated by androgen ablation therapy for advanced clinical prostate cancer and contributes to androgen independent cell growth

ABSTRACT: Androgen ablation therapy (AAT) is standard treatment for locally-advanced/metastatic prostate cancer (PCa). Many patients develop castration-resistance (CRPCa) after ~2-3 years, with a poor prognosis. The molecular mechanisms underlying CRPCa progression are unclear. mRNA-Seq was performed on tumours from 7 patients with locally-advanced/metastatic PCa before and ~22 weeks after AAT initiation. Differentially regulated genes were identified in treatment pairs. Tumour biopsies from 7 patients were taken before and after AAT treatment

ORGANISM(S): Homo sapiens

SUBMITTER: Ian Sudbery

PROVIDER: E-GEOD-48403 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy.

Rajan Prabhakar P Sudbery Ian M IM Villasevil M Eugenia M ME Mui Ernest E Fleming Janis J Davis Mark M Ahmad Imran I Edwards Joanne J Sansom Owen J OJ Sims David D Ponting Chris P CP Heger Andreas A McMenemin Rhona M RM Pedley Ian D ID Leung Hing Y HY

European urology 20130814 1

<h4>Background</h4>Androgen-deprivation therapy (ADT) is standard treatment for locally advanced or metastatic prostate cancer (PCa). Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear.<h4>Objective</h4>To undertake quantitative tumour transcriptome profiling prior to and following ADT to identify functionally important androgen-regulated pathways or gene ...[more]

PMID: 24054872

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