Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-seq of TALE fusions


ABSTRACT: We present a strategy to investigate regulatory elements that leverages programmable reagents to selectively inactivate their endogenous chromatin state. The reagents, which comprise fusions between transcription activator- like effector (TALE) repeat domains and the LSD1 histone demethylase, efficiently remove enhancer-associated chromatin modifications from target loci, without affecting control regions. We find that inactivation of enhancer chromatin by these fusions frequently causes down- regulation of proximal genes. Our study demonstrates the potential of 'epigenome editing' tools to characterize a critical class of functional genomic elements. ChIP-seq analysis of TALE-Fusion Proteins

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Mendenhall 

PROVIDER: E-GEOD-48866 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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