Genomics

Dataset Information

0

ChIP-seq of TALE fusions


ABSTRACT: We present a strategy to investigate regulatory elements that leverages programmable reagents to selectively inactivate their endogenous chromatin state. The reagents, which comprise fusions between transcription activator- like effector (TALE) repeat domains and the LSD1 histone demethylase, efficiently remove enhancer-associated chromatin modifications from target loci, without affecting control regions. We find that inactivation of enhancer chromatin by these fusions frequently causes down- regulation of proximal genes. Our study demonstrates the potential of 'epigenome editing' tools to characterize a critical class of functional genomic elements. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf

ORGANISM(S): Homo sapiens

PROVIDER: GSE48866 | GEO | 2013/07/26

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-07-26 | E-GEOD-48866 | biostudies-arrayexpress
2013-09-23 | E-GEOD-50761 | biostudies-arrayexpress
2013-09-23 | GSE50761 | GEO
2016-07-05 | GSE81897 | GEO
2016-07-05 | E-GEOD-81897 | biostudies-arrayexpress
2019-12-19 | GSE129193 | GEO
2013-05-31 | E-GEOD-45133 | biostudies-arrayexpress
2015-06-11 | GSE56978 | GEO
2015-05-28 | E-GEOD-67007 | biostudies-arrayexpress
2015-05-27 | E-GEOD-68341 | biostudies-arrayexpress