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The gene expression upon dominant negative form of GAS2 (GAS2DN) in MEG-01 cells

ABSTRACT: GAS2DN could suppress the growth of chronic myeloid leukemia cells, including K562, MEG-01 and CD34+ cells from patients. In addition, GAS2DN inhibited the tumorigenic ability of MEG-01 cells in nude mice. To understand the molecular insight of this inhibitory effect of GAS2DN, global gene expression were performed. The control and GAS2DN-transduced MEG-01 cells were used for microarray analysis. Three biological independent extracts of control and GAS2DN-transduced cells were pooled together with equal amount, and then the pooled samples were compared with Affymetrix chips.

ORGANISM(S): Homo sapiens

SUBMITTER: BaoHong Liu

PROVIDER: E-GEOD-49184 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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