KrasG12D partially compensates for the loss of beta-catenin in MLL-AF9 AML
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ABSTRACT: The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in MLL-AF9 AML. We evaluated the dependance on beta-catenin for KrasG12DMLL-AF9 leukemia. Lin-Kit+ bone marrow cells obtained from mice transplanted with primary MLL-AF9 leukemia cells and KRasG12DMLL-AF9 leukemia cells were assessed for gene expression in the presence or absence of beta-catenin
ORGANISM(S): Mus musculus
SUBMITTER: Amit Sinha
PROVIDER: E-GEOD-49248 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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