Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Genomic distribution of human histone H1 subtypes


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Albert Jordan 

PROVIDER: E-GEOD-49345 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2.

Millán-Ariño Lluís L   Islam Abul B M M K AB   Izquierdo-Bouldstridge Andrea A   Mayor Regina R   Terme Jean-Michel JM   Luque Neus N   Sancho Mónica M   López-Bigas Núria N   Jordan Albert A  

Nucleic acids research 20140129 7


Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Despite being key structural components of chromatin, it is not known whether the different variants have specific roles in the regulation of nuclear processes or are differentially distributed throughout the genome. Using variant-specific antibodies to H1 and hemagglutinin (HA)-tagged recombinant H1 variants expressed in breast cancer cells, we have investigated the distribution of si  ...[more]

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