Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Roberto Bonasio
PROVIDER: E-GEOD-49431 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature structural & molecular biology 20131020 11
EZH2 is the catalytic subunit of PRC2, a central epigenetic repressor essential for development processes in vivo and for the differentiation of embryonic stem cells (ESCs) in vitro. The biochemical function of PRC2 in depositing repressive H3K27me3 marks is well understood, but how it is regulated and directed to specific genes before and during differentiation remains unknown. Here, we report that PRC2 binds at low levels to a majority of promoters in mouse ESCs, including many that are active ...[more]