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Circadian gene expression from wild type MEFs

ABSTRACT: Expression profiles in WT MEF at different circadian time point after dexamethasone synchronization. We used the Affymetrix expression microarrays to detail the circadian gene expression from wild type mouse embryonic fibroblasts during a 24 hour circadian cycle. For each circadian time point (CT), three biological replicates were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Paolo Sassone-Corsi

PROVIDER: E-GEOD-49638 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cycles in spatial and temporal chromosomal organization driven by the circadian clock.

Aguilar-Arnal Lorena L Hakim Ofir O Patel Vishal R VR Baldi Pierre P Hager Gordon L GL Sassone-Corsi Paolo P

Nature structural & molecular biology 20130922 10

Dynamic transitions in the epigenome have been associated with regulated patterns of nuclear organization. The accumulating evidence that chromatin remodeling is implicated in circadian function prompted us to explore whether the clock may control nuclear architecture. We applied the chromosome conformation capture on chip technology in mouse embryonic fibroblasts (MEFs) to demonstrate the presence of circadian long-range interactions using the clock-controlled Dbp gene as bait. The circadian ge ...[more]

PMID: 24056944

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