Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of mice transgenic for LHCTP hyper secreting luteinizing hormone with cystic ovaries, luteoma or wild type to compare global changes in ovarian transcriptomes uniquely associated with either granulosa cell tumors or luteomas

ABSTRACT: Comparison of global changes in ovarian transcriptomes uniquely associated with either granulosa cell tumors or luteomas, and identification of new markers for this tumor phenotype. Luteinizing hormone hypersecreting mice studied.

ORGANISM(S): Mus musculus

DISEASE(S): normal

SUBMITTER: John Nilson

PROVIDER: E-GEOD-499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.

Owens Gabe E GE Keri Ruth A RA Nilson John H JH

Molecular endocrinology (Baltimore, Md.) 20020601 6

Granulosa cell tumors comprise approximately 10% of ovarian tumors and, although rare, are clinically important due to their potential for malignancy and recurrence. Although their morphological features have been carefully described, the global changes in gene expression associated with their formation remain undetermined. To initiate this characterization, we used a transgenic mouse model in which granulosa cell tumors occur with 100% penetrance in CF-1 mice that harbor a novel transgene encod ...[more]

PMID: 12040011

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Dataset Information

Transcription profiling of mice transgenic for LHCTP hyper secreting luteinizing hormone with cystic ovaries, luteoma or wild type to compare global changes in ovarian transcriptomes uniquely associated with either granulosa cell tumors or luteomas

Publications

Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.

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