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Over-expression of YAP1 in NCI-H716 colorectal cancer cells

ABSTRACT: YAP1 plays importance roles in development of colorectal cancer as evidenced by their overexpression in colorectal cancer and their expression promoted cell proliferation and survival of colorectal cancer cells. In order to understand potential roles of YAP1 in colorectal cancer, we over-expressed constitutively active YAP1 mutant in NCI-H716 colorectal cancer cells and identified and analyzed genes whose expression is activated by YAP1 activation in colorectal cancer. Pre-clinical study

ORGANISM(S): Homo sapiens

SUBMITTER: Sangbae Kim

PROVIDER: E-GEOD-50490 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients.

Lee Keun-Wook KW Lee Sung Sook SS Kim Sang-Bae SB Sohn Bo Hwa BH Lee Hyun-Sung HS Jang Hee-Jin HJ Park Yun-Yong YY Kopetz Scott S Kim Sung Soo SS Oh Sang Cheul SC Lee Ju-Seog JS

Clinical cancer research : an official journal of the American Association for Cancer Research 20141111 2

<h4>Purpose</h4>Activation of YAP1, a novel oncogene in the Hippo pathway, has been observed in many cancers, including colorectal cancer. We investigated whether activation of YAP1 is significantly associated with prognosis or treatment outcomes in colorectal cancer.<h4>Experimental design</h4>A gene expression signature reflecting YAP1 activation was identified in colorectal cancer cells, and patients with colorectal cancer were stratified into two groups according to this signature: activated ...[more]

PMID: 25388162

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