Melanoma brain metastases and matched extracranial metastases
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Guo Chen
PROVIDER: E-GEOD-50496 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.
Chen Guo G Chakravarti Nitin N Aardalen Kimberly K Lazar Alexander J AJ Tetzlaff Michael T MT Wubbenhorst Bradley B Kim Sang-Bae SB Kopetz Scott S Ledoux Alicia A AA Gopal Y N Vashisht YN Pereira Cristiano Goncalves CG Deng Wanleng W Lee Ju-Seog JS Nathanson Katherine L KL Aldape Kenneth D KD Prieto Victor G VG Stuart Darrin D Davies Michael A MA
Clinical cancer research : an official journal of the American Association for Cancer Research 20140506 21
<h4>Purpose</h4>An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between brain and extracranial metastases would support the need for the development of organ-specific therapeutic approaches.<h4>Experimental design</h4>Hotspot mutations, copy number variations ...[more]
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