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MicroRNA Profiling in Wilms Tumors and Kidney Tissues

ABSTRACT: The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bead platform.

ORGANISM(S): Homo sapiens

SUBMITTER: Sven Diederichs

PROVIDER: E-GEOD-50505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.

Liu Mingzhu M Roth Anna A Yu Min M Morris Robert R Bersani Francesca F Rivera Miguel N MN Lu Jun J Shioda Toshihiro T Vasudevan Shobha S Ramaswamy Sridhar S Maheswaran Shyamala S Diederichs Sven S Haber Daniel A DA

Genes & development 20131201 23

Insulin-like growth factor 2 (IGF2), a developmentally regulated and maternally imprinted gene, is frequently overexpressed in pediatric cancers. Although loss of imprinting (LOI) at fetal promoters contributes to increased IGF2 in tumors, the magnitude of IGF2 expression suggests the involvement of additional regulatory mechanisms. A microRNA (miRNA) screen of primary Wilms' tumors identified specific overexpression of miR-483-5p, which is embedded within the IGF2 gene. Unexpectedly, the IGF2 m ...[more]

PMID: 24298054

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