Unknown,Transcriptomics,Genomics,Proteomics

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Network Analysis Reveals a Novel Role for the AP-1 Transcription Factor JUNB in Classical and Alternative Macrophage Activation


ABSTRACT: Bone marrow-derived macrophages were generated from wild type and Junb knockout mice and tested for their responses to LPS treatment. Independent replicate wells from wild type and knockout bone marrow-derived macrophages were mock-treated or LPS-treated. RNA was isolated at 4 h post-treatment, amplified, and hybridized to Agilent Mouse 8x60k microarrays as a single color experiment.

ORGANISM(S): Mus musculus

SUBMITTER: Charlie Kim 

PROVIDER: E-GEOD-50542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

JUNB is a key transcriptional modulator of macrophage activation.

Fontana Mary F MF   Baccarella Alyssa A   Pancholi Nidhi N   Pufall Miles A MA   Herbert De'Broski R DR   Kim Charles C CC  

Journal of immunology (Baltimore, Md. : 1950) 20141203 1


Activated macrophages are crucial for restriction of microbial infection but may also promote inflammatory pathology in a wide range of both infectious and sterile conditions. The pathways that regulate macrophage activation are therefore of great interest. Recent studies in silico have putatively identified key transcription factors that may control macrophage activation, but experimental validation is lacking. In this study, we generated a macrophage regulatory network from publicly available  ...[more]

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