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Gene expression profile of C1013G/CXCR4 mutated WM cells

ABSTRACT: C1013G/CXCR4 variant has been inserted into BCWM.1 cells, and gene expression profile has been performed on the mutated cells and on the parental cells. Affimetrix Human Genome U133_Plus2.0 array We used microarrays to dissect the possible changes occurring at mRNA level in mutated cells versus the parental cellular counterpart.

ORGANISM(S): Homo sapiens

SUBMITTER: Aldo Roccaro

PROVIDER: E-GEOD-50683 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma.

Roccaro Aldo M AM Sacco Antonio A Jimenez Cristina C Maiso Patricia P Moschetta Michele M Mishima Yuji Y Aljawai Yosra Y Sahin Ilyas I Kuhne Michelle M Cardarelli Pina P Cohen Lewis L San Miguel Jesus F JF Garcia-Sanz Ramon R Ghobrial Irene M IM

Blood 20140407 26

The C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in modulating cell trafficking in hematopoietic stem cells and clonal B cells. We screened 418 patients with B-cell lymphoproliferative disorders and described the presence of the C1013G/CXCR4 warts, hypogammaglobulinemia, infections, and myelokathexis-associated mutation in 28.2% (37/131) of patients with lymphoplasmacytic lymphoma (Waldenström macroglobulinemia [WM]), being either absent or present in only 7% of other B-cell lymp ...[more]

PMID: 24711662

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