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Role of de novo DNA methyltransferases in hematopoietic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: deqiang sun

PROVIDER: E-GEOD-50793 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.

Challen Grant A GA Sun Deqiang D Mayle Allison A Jeong Mira M Luo Min M Rodriguez Benjamin B Mallaney Cates C Celik Hamza H Yang Liubin L Xia Zheng Z Cullen Sean S Berg Jonathan J Zheng Yayun Y Darlington Gretchen J GJ Li Wei W Goodell Margaret A MA

Cell stem cell 20140814 3

Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase Dnmt3a results in HSC expansion and impaired differentiation. Here, we report conditional inactivation of Dnmt3b in HSCs either alone or combined with Dnmt3a deletion. Combined loss of Dnmt3a and Dnmt3b was synergistic, resulting in enhanced HSC self-renewal and a more severe block in differentiation than in Dnmt3a-null ce ...[more]

PMID: 25130491

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