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HDAC inhibition by TSA and Butyrate In Flt3L-elicited DC

ABSTRACT: Butyrate induces Treg via HDACi activity Microarray of DC treated with TSA or Butyrate over untreated

ORGANISM(S): Mus musculus

SUBMITTER: Nicholas Arpaia

PROVIDER: E-GEOD-51263 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Arpaia Nicholas N Campbell Clarissa C Fan Xiying X Dikiy Stanislav S van der Veeken Joris J deRoos Paul P Liu Hui H Cross Justin R JR Pfeffer Klaus K Coffer Paul J PJ Rudensky Alexander Y AY

Nature 20131113 7480

Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection. The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut immune homeostasis, is affected by the composition of the commensal microbial community. Regulatory T cells (Treg cells) expressing transcription factor Foxp3 have a key role in limiting inflammatory responses in the intestine. Although specific members of the commensal microbial community have been found to poten ...[more]

PMID: 24226773

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Project description:Butyrate induces Treg via HDACi activity

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