Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Katarzyna Marcinkiewicz
PROVIDER: E-GEOD-51415 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Experimental cell research 20130925 1
To gain insight into oral squamous cell carcinogenesis, we performed deep sequencing (RNAseq) of non-tumorigenic human OKF6-TERT1R and tumorigenic SCC-9 cells. Numerous homeobox genes are differentially expressed between OKF6-TERT1R and SCC-9 cells. Data from Oncomine, a cancer microarray database, also show that homeobox (HOX) genes are dysregulated in oral SCC patients. The activity of Polycomb repressive complexes (PRC), which causes epigenetic modifications, and retinoic acid (RA) signaling ...[more]