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Altered Epigenetic Regulation of Homeobox Genes in Human Oral Squamous Cell Carcinoma Cells


ABSTRACT: To gain insight into the molecular changes during OSCC carcinogenesis, we performed unbiased, whole genome deep sequencing (RNA-seq) using RNA isolated from cultured, human TERT-immortalized, non-tumorigenic OKF6-TERT1R and OSCC SCC-9 cells. OKF6-TERT1R cells and SCC-9 cells were plated in 10 cm2 tissue culture plates at the density of 2 × 106 cells/plate and treated with 1 μM RA or vehicle (0.1% ethanol) for 48 hours. Experiment includes 3 independent biological replicates. Note: All samples in SRA were assigned the same sample accession (GSM1245064 1). This is incorrect as there are different samples, hence “Source Name” was replaced with new values. Comment[ENA_SAMPLE] contains the original SRA sample accessions.

ORGANISM(S): Homo sapiens

SUBMITTER: Katarzyna Marcinkiewicz 

PROVIDER: E-GEOD-51415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.

Marcinkiewicz Katarzyna M KM   Gudas Lorraine J LJ  

Experimental cell research 20130925 1


To gain insight into oral squamous cell carcinogenesis, we performed deep sequencing (RNAseq) of non-tumorigenic human OKF6-TERT1R and tumorigenic SCC-9 cells. Numerous homeobox genes are differentially expressed between OKF6-TERT1R and SCC-9 cells. Data from Oncomine, a cancer microarray database, also show that homeobox (HOX) genes are dysregulated in oral SCC patients. The activity of Polycomb repressive complexes (PRC), which causes epigenetic modifications, and retinoic acid (RA) signaling  ...[more]

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