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Transcription profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.

ABSTRACT: The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision that conventional while light (WL) imaging. Samples were taken prospectively from 18 patients undergoing surgical resection for intraoral SCC (excluding lip, pharynx and hypopharynx). Biopsies were taken from the tumour and from 5mm beyond each of the abnormal tissue margins defined by WL and NBI. Transcriptional profiling was performed by microarray.

ORGANISM(S): Homo sapiens

SUBMITTER: Camile Farah

PROVIDER: E-MTAB-5933 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Improved surgical margin definition by narrow band imaging for resection of oral squamous cell carcinoma: A prospective gene expression profiling study.

Farah Camile S CS Dalley Andrew J AJ Nguyen Phan P Batstone Martin M Kordbacheh Farzaneh F Perry-Keene Joanna J Fielding David D

Head & neck 20150626 6

<h4>Background</h4>Incomplete primary tumor excision contributes to localized postsurgical recurrence of oral squamous cell carcinoma (OSCC). The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision than conventional white light (WL) panendoscopy.<h4>Methods</h4>Molecular divergence among tumor, WL, and NBI-defined surgical margins was compared in 18 patients through microarray analysis (Ge ...[more]

PMID: 25545703

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MicroRNA profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.

Project description:The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision that conventional while light (WL) imaging. Samples were taken prospectively from 18 patients undergoing surgical resection for intraoral SCC (excluding lip, pharynx and hypopharynx). Biopsies were taken from the tumour and from 5mm beyond each of the abnormal tissue margins defined by WL and NBI. MicroRNA profiling was performed by microarray.

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