Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.


ABSTRACT: The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision that conventional while light (WL) imaging. Samples were taken prospectively from 18 patients undergoing surgical resection for intraoral SCC (excluding lip, pharynx and hypopharynx). Biopsies were taken from the tumour and from 5mm beyond each of the abnormal tissue margins defined by WL and NBI. MicroRNA profiling was performed by microarray.

ORGANISM(S): Homo sapiens

SUBMITTER: Simon Fox 

PROVIDER: E-MTAB-6470 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrated miRNA-mRNA spatial signature for oral squamous cell carcinoma: a prospective profiling study of Narrow Band Imaging guided resection.

Farah Camile S CS   Fox Simon A SA   Dalley Andrew J AJ  

Scientific reports 20180116 1


Oral squamous cell carcinoma (OSCC) is a common malignancy for which there is poor prognosis and limited therapeutic options. The objective was to identify mRNA targets of dysregulated miRNAs in OSCC using integrated analysis and understand molecular abnormality in surgical margins. We used biopsies along the spatial axis from normal tissue defined by narrow band imaging (NBI) through conventional white light (WL) margins to tumour from 18 patients undergoing surgical resection for OSCC. Overall  ...[more]

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