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Unknown,Transcriptomics,Genomics,Proteomics

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Genome wide transcriptional profiling of HIV positive and negative children with active tuberculosis, latent TB infection and other diseases

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Victoria Wright

PROVIDER: E-GEOD-39941 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Diagnosis of childhood tuberculosis and host RNA expression in Africa.

Anderson Suzanne T ST Kaforou Myrsini M Brent Andrew J AJ Wright Victoria J VJ Banwell Claire M CM Chagaluka George G Crampin Amelia C AC Dockrell Hazel M HM French Neil N Hamilton Melissa S MS Hibberd Martin L ML Kern Florian F Langford Paul R PR Ling Ling L Mlotha Rachel R Ottenhoff Tom H M THM Pienaar Sandy S Pillay Vashini V Scott J Anthony G JAG Twahir Hemed H Wilkinson Robert J RJ Coin Lachlan J LJ Heyderman Robert S RS Levin Michael M Eley Brian B

The New England journal of medicine 20140501 18

<h4>Background</h4>Improved diagnostic tests for tuberculosis in children are needed. We hypothesized that transcriptional signatures of host blood could be used to distinguish tuberculosis from other diseases in African children who either were or were not infected with the human immunodeficiency virus (HIV).<h4>Methods</h4>The study population comprised prospective cohorts of children who were undergoing evaluation for suspected tuberculosis in South Africa (655 children), Malawi (701 children ...[more]

PMID: 24785206

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Genome wide transcriptional profiling of HIV positive and negative children with active tuberculosis, latent TB infection and other diseases from Kenya

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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A protein network of common susceptibility genes provides a link in the genetic architecture of chronic inflammation and cardiovascular disease

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