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Inferring the stress-activated signaling network in yeast through multi-omic data integration

ABSTRACT: Transcriptome profiling of yeast mutant strains responding to 0.7M NaCl treatment for 30 minutes. This study identified affected genes in each mutant and used it to computationally infer the complete NaCl-activated signaling network in yeast. Two-color fluorescence arrays reporting on mRNA abundance in strains before and at 30 min after a shock with 0.7M NaCl, hybridized to yeast tile-genome Nimblegen arrays

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Audrey Gasch 

PROVIDER: E-GEOD-51844 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pathway connectivity and signaling coordination in the yeast stress-activated signaling network.

Chasman Deborah D   Ho Yi-Hsuan YH   Berry David B DB   Nemec Corey M CM   MacGilvray Matthew E ME   Hose James J   Merrill Anna E AE   Lee M Violet MV   Will Jessica L JL   Coon Joshua J JJ   Ansari Aseem Z AZ   Craven Mark M   Gasch Audrey P AP  

Molecular systems biology 20141119

Stressed cells coordinate a multi-faceted response spanning many levels of physiology. Yet knowledge of the complete stress-activated regulatory network as well as design principles for signal integration remains incomplete. We developed an experimental and computational approach to integrate available protein interaction data with gene fitness contributions, mutant transcriptome profiles, and phospho-proteome changes in cells responding to salt stress, to infer the salt-responsive signaling net  ...[more]

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