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Coordination and interconnectivity in the inferred stress-activated signaling network from yeast

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Audrey Gasch

PROVIDER: E-GEOD-60613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pathway connectivity and signaling coordination in the yeast stress-activated signaling network.

Chasman Deborah D Ho Yi-Hsuan YH Berry David B DB Nemec Corey M CM MacGilvray Matthew E ME Hose James J Merrill Anna E AE Lee M Violet MV Will Jessica L JL Coon Joshua J JJ Ansari Aseem Z AZ Craven Mark M Gasch Audrey P AP

Molecular systems biology 20141119

Stressed cells coordinate a multi-faceted response spanning many levels of physiology. Yet knowledge of the complete stress-activated regulatory network as well as design principles for signal integration remains incomplete. We developed an experimental and computational approach to integrate available protein interaction data with gene fitness contributions, mutant transcriptome profiles, and phospho-proteome changes in cells responding to salt stress, to infer the salt-responsive signaling net ...[more]

PMID: 25411400

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