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HEK293 cells (HEK293-CT) and HEK293 cells stably over-expressing the BAHD1 gene (HEK-BAHD1)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Emanuele Libertini

PROVIDER: E-GEOD-51868 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome.

Libertini Emanuele E Lebreton Alice A Lakisic Goran G Dillies Marie-Agnès MA Beck Stephan S Coppée Jean-Yves JY Cossart Pascale P Bierne Hélène H

Frontiers in genetics 20151201

BAH domain-containing protein 1 (BAHD1) is involved in heterochromatin formation and gene repression in human cells. BAHD1 also localizes to the inactive X chromosome (Xi), but the functional significance of this targeting is unknown. So far, research on this protein has been hampered by its low endogenous abundance and its role in epigenetic regulation remains poorly explored. In this work, we used whole-genome bisulfite sequencing (BS-seq) to compare the DNA methylation profile of HEK293 cells ...[more]

PMID: 26648976

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