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A crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Salam Assi

PROVIDER: E-GEOD-52499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Gilmour Jane J Assi Salam A SA Jaegle Ulrike U Kulu Divine D van de Werken Harmen H Clarke Deborah D Westhead David R DR Philipsen Sjaak S Bonifer Constanze C

Development (Cambridge, England) 20140521 12

Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knockout mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here, we have used conditional knockout mice as well as the differentiation of mouse ES cells as a model with which to address this issue. To this end, we examined differentiation potential, global gene expre ...[more]

PMID: 24850855

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