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Genome-wide detection by array CGH of copy number variations among diverse horse breeds

ABSTRACT: Investigating genome-wide characteristics of CNVs in 6 horses representing 6 distinct breeds by using the aCGH method and performed GO and KEGG analysis for the CNVs genes.This result is an important complement to the mapping of horse whole-genome CNVs and helpful to study plateau horsesM-bM-^@M-^Y adaption to the plateauM-bM-^@M-^Ys environment. Comparison Mongolia horse , Abaga horse, Hequ horse, Kazakh horse, Debao pony, Thoroughbred with Thoroughbred

ORGANISM(S): Equus caballus

SUBMITTER: Wei Wang

PROVIDER: E-GEOD-52504 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide detection by array CGH of copy number variations among diverse horse breeds

Project description:Investigating genome-wide characteristics of CNVs in 6 horses representing 6 distinct breeds by using the aCGH method and performed GO and KEGG analysis for the CNVs genes.This result is an important complement to the mapping of horse whole-genome CNVs and helpful to study plateau horses’ adaption to the plateau’s environment.

2014-02-26 | GSE52504 | GEO

CGH analysis of androgenetic haploid embryonic stem cells

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Analysis of Genomic Copy Number Variation in Equine Recurrent Airway Obstruction

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Equine dendritic cells generated with horse serum have enhanced functionality in comparison to dendritic cells generated with fetal bovine serum

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2016-07-06 | E-GEOD-84031 | biostudies-arrayexpress

CGH analysis of AG-haESCs (androgenetic haploid embryonic stem cells)

Project description:The genomic DNA sample of AG-haESCs were compared to the C57BL/6J male mouse kidney by comparative genomic hybridization. The data confirmed that the haploid cells sustained genome integrity. The analysis was performed on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array to analyse the copy number variations in AG-haESCs, and the genomic DNA of C57BL/6J male mouse kidney was used as control, which had the same background with haploid ESCs.

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A composite map of copy number variable (CNV) regions in the horse genome and the discovery of CNVs involved in equine XY disorders of sexual development

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Metabolomic Diagnosis in Horse

Project description:In this project we will investigate the feasibility of metabolomics and to characterize the diversity of metabotypes in the horse, towards discovery of markers and pathways associated with obesity and insulin resistance in the equine model. The collaborative team of researchers assembled for this work have identified horses severely affected with Equine Metabolic syndrome, often characterized by obesity and hyperinsulinemia. These animals are all from the Arabian breed, to control for some genetic background. Horses are age, sex and farm of residence matched with a control animal whenever possible. Carefully controlled collection protocols were utilized to ensure minimal variability in sample age and quality. Blood plasma is submitted for both global LC-MS analysis through the SECIM core facilities. This discovery-based approach will begin to generate new targets for the development of novel therapeutic interventions for the treatment and prevention of obesity, type-2 diabetes as well as related secondary conditions in both humans and horses. Finally, as the first dataset of its kind in the horse, we may also be able to highlight promising new biomarkers for veterinary diagnostic use.

2015-10-13 | ST000244 | MetabolomicsWorkbench

Next Generation Sequencing Transcriptomic Analysis (RNA-seq) of Thoroughbred horse at rest, after exercise and after training

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Profiling of differential allelic expression in horse, donkey, mule, and hinny placental tissues.

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