Ontology highlight
ABSTRACT:
ORGANISM(S): Moraxella catarrhalis BBH18
SUBMITTER: Hester Bootsma
PROVIDER: E-GEOD-52552 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular microbiology 20131218 3
The complement system is an important innate defence mechanism, and the ability to resist complement-mediated killing is considered a key virulence trait of the respiratory tract pathogen M. catarrhalis. We studied the molecular basis of complement resistance by transcriptional profiling and Tn-seq, a genome-wide negative-selection screenings technology. Exposure of M. catarrhalis to human serum resulted in increased expression of 84 genes and reduced expression of 134 genes, among which genes e ...[more]