Dataset Information
Transcription profiling of human cell lines freely cycling treated with 164 distinct small molecules - Broad Connectivity Map CMAP Set 1
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Justin Lamb
PROVIDER: E-GEOD-5258 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
Science (New York, N.Y.) 20060901 5795
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and ...[more]
