Unknown,Transcriptomics,Genomics,Proteomics

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Liver expression data from four mouse strains treated with vehicle or PF-04287881 for seven days


ABSTRACT: PF-04287881 induced varying degrees of liver necrosis and phospholipidosis in a 34-inbred strain Mouse Diversity Panel (MDP) study. Four strains with differing susceptibilities to these phenotypes (MA/MyJ, NZW/LacJ, SM/J, WSB/EiJ) were selected for analysis of gene expression changes in the liver. The objective of this study was to identify gene expression changes that drive PF-04287881-induced liver injury. Thirty-one total samples were analyzed: N=4 per treatment and strain, except PF-04287881-treated WSB/EiJ (N=3) where one animal died before the completion of the study due to gavage error. Two strains exhibited findings of PF-04287881-induced Kupffer cell vacuolation and were coded as phospholipidosis responders (MA/MyJ and NZW/LacJ). One strain exhibited findings of single cell necrosis and was coded as a necrosis responder (NZW/LacJ).

ORGANISM(S): Mus musculus

SUBMITTER: Merrie Mosedale 

PROVIDER: E-GEOD-52620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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