Proteomics

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Genetic context modulates aging and degeneration in the murine retina

ABSTRACT: This is the proteomics component of a multi-omics analysis of the aging murine retina. Age is a critical risk factor for vision-threatening retinopathies. Susceptibility to age-related retinal neurodegeneration is genetically influenced, however, no studies have addressed molecular retinal aging signatures across genetically diverse populations. Here, we profile retinal proteomics in an array of genetically diverse mice with age. Proteomics were employed to profile retinal aging signatures in C57BL/6J (B6), 129S1/SvImJ, NZO/HlLtJ (NZO), WSB/EiJ (WSB), CAST/EiJ, PWK/PhJ, NOD/ShiLtJ, A/J, and BALB/cJ mouse strains at 4, 12, and 18M. These data were collated into a publicly available resource.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

DISEASE(S): Retinal Degeneration

SUBMITTER: Michael MacLean  

LAB HEAD: Gareth Howell

PROVIDER: PXD057861 | Pride | 2025-01-23

REPOSITORIES: pride

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20230410_GH_Retina_TMT-10_16plex_Multiplex10.mzML Mzml
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Genetic context modulates aging and degeneration in the murine retina.

Marola Olivia J OJ   MacLean Michael M   Cossette Travis L TL   Diemler Cory A CA   Hewes Amanda A AA   Reagan Alaina M AM   Kanyinda Jonathan Nyandu JN   Skelly Daniel A DA   Howell Gareth R GR  

Molecular neurodegeneration 20250120 1

<h4>Background</h4>Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biological properties; thus, insights into retinal aging and degeneration may shed light onto similar processes in the brain. Genetic makeup strongly influences susceptibility to age-related retinal disease. However, studies investigating retinal aging have not sufficiently accounted for genetic diversity. Therefore, examining molecular aging in the retina acros  ...[more]

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