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Allele-specific expression in liver, hypothalamus and vomeronasal organ of Mus.m.musculus and M.m. domesticus

ABSTRACT: We performed RNaseq of liver, hypothalamus and vomeronasal organ crosses between inbred stains of M. m. domesticus (strain WSB/EiJ) and M. m. musculus (PWD/PhJ). We also sequenced RNA from the same tissues from parental M. m. musculus (PWD/PhJ).

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Diethard Tautz

PROVIDER: E-MTAB-3288 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Angiotensin-neprilysin inhibition versus enalapril in heart failure.

McMurray John J V JJ Packer Milton M Desai Akshay S AS Gong Jianjian J Lefkowitz Martin P MP Rizkala Adel R AR Rouleau Jean L JL Shi Victor C VC Solomon Scott D SD Swedberg Karl K Zile Michael R MR

The New England journal of medicine 20140830 11

<h4>Background</h4>We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.<h4>Methods</h4>In this double-blind trial, we randomly assigned 8442 patients with class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either LCZ696 (at a dose of 200 mg twice daily) or enalapril (at a dose of 10 mg twice daily), in ...[more]

PMID: 25176015

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