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Thermus thermophilus HB27 WT vs HB27Δago RNAseq

ABSTRACT: raw RNAseq data from mid-log phase Thermus thermophilus HB27 WT and HB27Δago RNA Biological triplicates for each strain

ORGANISM(S): Thermus thermophilus HB8

SUBMITTER: daan swarts

PROVIDER: E-GEOD-52738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA-guided DNA interference by a prokaryotic Argonaute.

Swarts Daan C DC Jore Matthijs M MM Westra Edze R ER Zhu Yifan Y Janssen Jorijn H JH Snijders Ambrosius P AP Wang Yanli Y Patel Dinshaw J DJ Berenguer José J Brouns Stan J J SJJ van der Oost John J

Nature 20140216 7491

RNA interference is widely distributed in eukaryotes and has a variety of functions, including antiviral defence and gene regulation. All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide proteins of the Argonaute (Ago) family to complementary ssRNA targets: RNA-guided RNA interference. The role of prokaryotic Ago variants has remained elusive, although bioinformatics analysis has suggested their involvement in host defence. Here we demonstrate that Ago of the ...[more]

PMID: 24531762

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